Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3957230 | 0.78 | ALDH1A1 (0.39) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL4976851 | 0.74 | TRAP1 (0.39) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL3950564 | 0.74 | CYP1A2 (0.43) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL4979292 | 0.74 | CYP1A2 (0.43) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL3954631 | 0.73 | IDO1 (0.41) | MAPTKMT2AAKR1B1 | |
| SCHEMBL5135636 | 0.71 | DAO (0.37) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL3952569 | 0.70 | OPRM1 (0.44) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL4169552 | 0.66 | AKR1B1 (0.45) | AKR1B1 | |
| SCHEMBL4979612 | 0.66 | TP53 (0.39) | CYP1A2MAPTCYP2C19KMT2AAKR1B1 | |
| SCHEMBL4979242 | 0.63 | POLB (0.43) | CYP1A2MAPTCYP2C19KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013216-A2 | NOVEL SPIRO [IMIDAZOLIDINE-4, 3' -INDOLE] 2, 2', 5' (1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | AstraZeneca AB (SE) | 2009-01-14 | — | — | EP | claimed |
| WO-2007091948-A2 | NOVEL SPIRO [IMIDAZOLIDINE-4, 3´-INDOLE] 2, 2´,5´(1H) TRIONES FOR TREATMENT OF CONDITIONS ASSOCIATED WITH VANILLOID RECEPTOR 1 | ASTRAZENECA AB (SE) | 2007-08-16 | — | — | WO | claimed |