Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | THRA | P10827 | 2/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3884343 | 0.86 | THRB (0.34) | PTGS1PTGS2TAS1R3TAS1R1LMNA | |
| SCHEMBL3146786 | 0.86 | THRB (0.47) | PTGS1PTGS2TAS1R3TAS1R1LMNA | |
| SCHEMBL28758420 | 0.84 | CYP3A4 (0.38) | PTGS1PTGS2LMNATHRBSMN1; SMN2 | |
| SCHEMBL282207 | 0.83 | LMNA (0.32) | PTGS1PTGS2TAS1R3TAS1R1LMNA | |
| SCHEMBL7114179 | 0.75 | PTGS1 (0.50) | PTGS1PTGS2LMNAHPGDNPSR1 | |
| SCHEMBL8498059 | 0.73 | THRB (0.49) | PTGS1PTGS2LMNATHRBHSD17B10 | |
| SCHEMBL7119331 | 0.70 | PTGS1 (0.50) | PTGS1PTGS2LMNARAB9AHSD17B10 | |
| SCHEMBL13381631 | 0.70 | THRB (0.56) | THRBTHRA | |
| SCHEMBL685031 | 0.69 | PDE4A (0.35) | PTGS1PTGS2THRBEGFRMEN1 | |
| SCHEMBL282132 | 0.68 | THRB (0.66) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891080-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | Metabasis Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| WO-2006128055-A2 | NOVEL PHOSPHORUS-CONTAINING THYROMIMETICS | METABASIS THERAPEUTICS, INC. (US) | 2006-11-30 | — | — | WO | disclosed |