Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961305 | 0.71 | GAA (0.34) | GAAMAPTPARP1 | |
| SCHEMBL30816200 | 0.69 | PARP1 (0.35) | GAAMAPTPARP1 | |
| SCHEMBL2708889 | 0.68 | KDM4E (0.34) | GAAMAPTKDM4EPKMPARP1 | |
| SCHEMBL2711333 | 0.68 | CACNB4 (0.34) | GAAMAPTKDM4EPKMPARP1 | |
| SCHEMBL15701846 | 0.67 | MEN1 (0.33) | MAPTKDM4EPKM | |
| SCHEMBL30817704 | 0.65 | PDE7A (0.41) | — | |
| SCHEMBL18403739 | 0.65 | OXTR (0.32) | KDM4EPKM | |
| SCHEMBL17023952 | 0.64 | LMNA (0.30) | — | |
| SCHEMBL6981687 | 0.63 | THRB (0.35) | — | |
| SCHEMBL7714689 | 0.63 | KDM4E (0.30) | KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1998775-A2 | BIS1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USES AS PHARMACEUTICALS | Université de Liège (BE) | 2008-12-10 | — | — | EP | disclosed |
| WO-2007107442-A2 | BIS1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES AND THEIR USES AS PHARMACEUTICALS | UNIVERSITE DE LIEGE (BE) | 2007-09-27 | — | — | WO | disclosed |