Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL694333 | 0.95 | KMT2A (0.50) | KMT2AMEN1MGLLGPR119MAPT | |
| SCHEMBL5136398 | 0.83 | KMT2A (0.52) | KMT2AMEN1MGLLMAPTKDM4E | |
| SCHEMBL4734659 | 0.82 | CYP2D6 (0.61) | KMT2AMEN1MGLLMAPTKDM4E | |
| SCHEMBL4013471 | 0.82 | KMT2A (0.67) | KMT2AMEN1MGLLGPR119MAPT | |
| SCHEMBL16117974 | 0.80 | KMT2A (0.46) | KMT2AMEN1MGLLGPR119MAPT | |
| SCHEMBL16822551 | 0.80 | KMT2A (0.46) | KMT2AMEN1MGLLGPR119ATM | |
| SCHEMBL16117985 | 0.80 | KMT2A (0.46) | KMT2AMEN1MGLLGPR119ATM | |
| SCHEMBL16822486 | 0.80 | SLC6A9 (0.43) | KMT2AMEN1MGLLGPR119ATM | |
| SCHEMBL16822525 | 0.80 | SLC6A9 (0.43) | KMT2AMEN1MGLLGPR119ATM | |
| SCHEMBL15000993 | 0.79 | GPR119 (0.64) | GPR119MAPTKDM4EL3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899318-A1 | NEW AZETIDINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS FOR THE TREATMENT OF GASTROINTESTINAL DISEASES | AstraZeneca AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006137791-A1 | NEW AZETIDINE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS FOR THE TREATMENT OF GASTROINTESTINAL DISEASES | ASTRAZENECA AB (SE) | 2006-12-28 | — | — | WO | disclosed |
| US-6262046-B1 | Azetidinylpropylpiperidine derivatives, intermediates and use as tachykinin antagonists | PFIZER INC. | 2001-07-17 | — | — | US | disclosed |