Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 4/20 | 0.33 |
| ▸ | THRA | P10827 | 5/20 | 0.33 |
| ▸ | THRB | P10828 | 5/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5136430 | 0.89 | MEN1 (0.39) | MEN1KMT2APOLBPDE10APPARG | |
| SCHEMBL3137299 | 0.85 | THRA (0.39) | MEN1KMT2APOLBPDE10APPARG | |
| SCHEMBL3142062 | 0.83 | THRA (0.38) | PDE10APPARGTHRATHRB | |
| SCHEMBL4529353 | 0.79 | MEN1 (0.34) | MEN1KMT2APOLBTHRATHRB | |
| SCHEMBL3131701 | 0.72 | ACSS2 (0.48) | PDE10APPARGTHRATHRB | |
| SCHEMBL3140970 | 0.71 | THRA (0.35) | PPARGTHRATHRB | |
| SCHEMBL3141794 | 0.70 | THRA (0.40) | MEN1KMT2ATHRATHRBLMNA | |
| SCHEMBL3129981 | 0.70 | THRA (0.56) | POLBTHRATHRB | |
| SCHEMBL3137483 | 0.69 | THRA (0.41) | PPARGTHRATHRBLMNA | |
| SCHEMBL3137491 | 0.69 | THRA (0.41) | PPARGTHRATHRBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899309-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003419-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2007-01-11 | — | — | WO | disclosed |