Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | THRA | P10827 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4529355 | 0.89 | MEN1 (0.36) | MEN1KMT2ALMNATSHRSMN1; SMN2 | |
| SCHEMBL3137471 | 0.83 | THRB (0.53) | MEN1KMT2AHDAC6POLBALOX5AP | |
| SCHEMBL5136428 | 0.79 | MEN1 (0.37) | MEN1KMT2ALMNATSHRSMN1; SMN2 | |
| SCHEMBL3136227 | 0.70 | HDAC1 (0.38) | MEN1KMT2ALMNAHDAC1HDAC8 | |
| SCHEMBL3142062 | 0.66 | THRA (0.38) | THRATHRB | |
| SCHEMBL29016571 | 0.65 | CNR2 (0.41) | MEN1KMT2ALMNATSHRHDAC6 | |
| SCHEMBL3137299 | 0.65 | THRA (0.39) | MEN1KMT2APOLBTHRATHRB | |
| SCHEMBL29016550 | 0.64 | RORC (0.40) | LMNA | |
| SCHEMBL29016631 | 0.63 | RORC (0.46) | CNR2 | |
| SCHEMBL29016642 | 0.61 | MEN1 (0.41) | MEN1KMT2ASMN1; SMN2POLBCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | disclosed |