Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSPO | P30536 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845050 | 0.81 | MAPT (0.37) | MAPTKDM4ETP53 | |
| SCHEMBL1728322 | 0.75 | ALDH1A1 (0.35) | MAPTTSPOKDM4ENPSR1TP53 | |
| SCHEMBL27883300 | 0.73 | KDM4E (0.33) | MAPTKDM4ENPSR1 | |
| SCHEMBL5139 | 0.67 | CNR1 (0.39) | KDM4ENPSR1 | |
| SCHEMBL8613 | 0.66 | TP53 (0.43) | MAPTTSPOKDM4ENPSR1TP53 | |
| SCHEMBL5526 | 0.64 | ALDH1A1 (0.55) | MAPTKDM4E | |
| SCHEMBL17078095 | 0.62 | TSHR (0.48) | MAPTKDM4ETP53 | |
| SCHEMBL6306623 | 0.61 | SMN1; SMN2 (0.47) | KDM4ETP53 | |
| SCHEMBL20521552 | 0.61 | JAK2 (0.33) | — | |
| SCHEMBL2553564 | 0.60 | PTK2 (0.44) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432784-A1 | FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB Pharma, S.A. (BE) | 2012-03-28 | — | — | EP | disclosed |
| WO-2011058109-A1 | FUSED BICYCLIC PYRROLE AND IMIDAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2011-05-19 | — | — | WO | disclosed |
| WO-2010133836-A1 | FUSED BICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-11-25 | — | — | WO | disclosed |