SCHEMBL5138722

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL3247680	0.85	TGFBR1 (0.55)	TGFBR1
	SCHEMBL4160099	0.80	TGFBR1 (0.49)	TGFBR1TGFBR2DYRK1A
	SCHEMBL3855569	0.74	TGFBR1 (0.50)	TGFBR1TGFBR2
	SCHEMBL5138707	0.74	TGFBR1 (0.45)	TGFBR1MAPTTGFBR2NPC1RAB9A
	SCHEMBL27628474	0.73	TGFBR1 (0.49)	TGFBR1SMN1; SMN2KDM4ENPC1KDR
	SCHEMBL3243384	0.73	TGFBR1 (0.43)	TGFBR1
	SCHEMBL3240954	0.73	TGFBR1 (0.43)	TGFBR1AKT1AKT2
	SCHEMBL3463943	0.71	KDM4E (0.48)	MAPTHTTSMN1; SMN2TDP1KDM4E
	SCHEMBL5490810	0.71	TGFBR1 (0.54)	TGFBR1KDM4EPOLB
	SCHEMBL8489109	0.71	L3MBTL1 (0.44)	TGFBR1HTTSMN1; SMN2KDM4ETP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.