Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18342156 | 0.96 | SMN1; SMN2 (0.36) | GAASMN1; SMN2LMNAPOLBKMT2A | |
| SCHEMBL27500622 | 0.75 | OPRD1 (0.45) | GAASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL14463170 | 0.75 | ALDH1A1 (0.47) | SMN1; SMN2LMNAPOLBKMT2AMEN1 | |
| SCHEMBL5202981 | 0.74 | ALDH1A1 (0.45) | SMN1; SMN2LMNAKMT2AMEN1ALDH1A1 | |
| SCHEMBL8484892 | 0.74 | JAK3 (0.33) | HPGD | |
| SCHEMBL30101056 | 0.71 | — | — | |
| SCHEMBL31386973 | 0.71 | L3MBTL1 (0.38) | KMT2AMEN1L3MBTL1 | |
| SCHEMBL16086201 | 0.70 | ALDH1A1 (0.48) | SMN1; SMN2LMNAPOLBKMT2AMEN1 | |
| SCHEMBL4719492 | 0.70 | ALDH1A1 (0.48) | SMN1; SMN2LMNAPOLBALDH1A1MAPT | |
| SCHEMBL30665505 | 0.70 | ALDH1A1 (0.31) | SMN1; SMN2LMNAALDH1A1TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904474-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007008140-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2007-01-18 | — | — | WO | disclosed |