Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 11/20 | 0.49 |
| ▸ | HTR1A | P08908 | 10/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.41 |
| ▸ | DCK | P27707 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | NMT1 | P30419 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL83203 | 0.80 | SLC6A2 (0.62) | SLC6A2HTR1ASLC6A3SLC6A4NMT1 | |
| SCHEMBL5046732 | 0.80 | TDO2 (0.41) | SLC6A2HTR1ASLC6A3TDO2NMT1 | |
| Hydrochloric Acid SCHEMBL69817 | 0.79 | HTR1A (0.60) | SLC6A2HTR1ASLC6A3TDO2SLC6A4 | |
| SCHEMBL16384743 | 0.76 | GPR119 (0.52) | SLC6A2HTR1ASLC6A3TDO2SLC6A4 | |
| SCHEMBL29003870 | 0.75 | TDO2 (0.50) | SLC6A2HTR1ASLC6A3TDO2SLC6A4 | |
| SCHEMBL389562 | 0.74 | GPR119 (0.71) | GPR119 | |
| SCHEMBL4722977 | 0.73 | GPR119 (0.55) | DCKCHRM4GPR119 | |
| SCHEMBL23161332 | 0.72 | SLC6A2 (0.64) | SLC6A2HTR1ASLC6A3SLC6A4HTR2C | |
| SCHEMBL941030 | 0.71 | SLC6A2 (0.58) | SLC6A2HTR1ASLC6A3SLC6A4NMT1 | |
| Hydrochloric Acid SCHEMBL23146510 | 0.71 | SLC6A2 (0.62) | SLC6A2HTR1ASLC6A3SLC6A4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2004157-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AS WELL AS COMBINATION THERAPY RELATING THERETO | Arena Pharmaceuticals, Inc. (US) | 2008-12-24 | — | — | EP | disclosed |
| WO-2007120702-A2 | USE OF GPR119 RECEPTOR AGONISTS FOR INCREASING BONE MASS AND FOR TREATING OSTEOPOROSIS, AND COMBINATION THERAPY RELATING THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2007-10-25 | — | — | WO | disclosed |