Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513805 | 0.79 | KDM4E (0.46) | ALDH1A1RAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL17773148 | 0.75 | CYP19A1 (0.46) | NTMT1ALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL513433 | 0.72 | TSHR (0.36) | ALDH1A1RAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL10475796 | 0.72 | HPGD (0.45) | ALDH1A1RAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL513979 | 0.72 | TDP1 (0.40) | ALDH1A1RAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL512093 | 0.71 | NPC1 (0.41) | ALDH1A1RAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL22013523 | 0.69 | ADORA3 (0.46) | ALDH1A1RAB9ANPC1HPGDSMN1; SMN2 | |
| SCHEMBL5010542 | 0.68 | PGK1 (0.53) | ALDH1A1PKMMEN1KMT2ATSHR | |
| SCHEMBL17742730 | 0.67 | CYP19A1 (0.44) | NTMT1ALDH1A1RAB9ANPC1HPGD | |
| SCHEMBL10144382 | 0.67 | CYP19A1 (0.50) | ALDH1A1RAB9ANPC1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | NTMT1 1517/4885ALDH1A1 2610/4885RAB9A 2058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.