Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4950754 | 0.91 | SCN5A (0.37) | SCN9ASCN5AGRM5ROCK2ROCK1 | |
| SCHEMBL4949007 | 0.89 | GRM5 (0.36) | SCN9ASCN5AGRM5ROCK2ROCK1 | |
| SCHEMBL4950102 | 0.88 | PTGS1 (0.41) | SCN9ASCN5AGRM5MAP4K4ROCK2 | |
| SCHEMBL4947779 | 0.82 | SCN9A (0.47) | SCN9ASCN5AGRM5MAP4K4 | |
| SCHEMBL4947778 | 0.82 | SCN9A (0.47) | SCN9ASCN5AGRM5MAP4K4 | |
| SCHEMBL4949577 | 0.81 | ALDH1A1 (0.42) | — | |
| SCHEMBL4952472 | 0.81 | F11 (0.35) | SCN9AMAP4K4 | |
| SCHEMBL4952527 | 0.80 | PTGS2 (0.36) | SCN9A | |
| SCHEMBL4953059 | 0.78 | PTGS1 (0.37) | — | |
| SCHEMBL4950027 | 0.76 | TDP1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893597-A2 | AMPA RECEPTOR POTENTIATORS | ELI LILLY AND COMPANY (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006132811-A2 | AMPA RECEPTOR POTENTIATORS | ELI LILLY AND COMPANY (US) | 2006-12-14 | — | — | WO | disclosed |