Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PTGIR | P43119 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400582 | 0.89 | NPSR1 (0.44) | NPSR1ATMTDP1L3MBTL1PTGIR | |
| SCHEMBL6905225 | 0.83 | KMT2A (0.46) | NPSR1ATMTDP1L3MBTL1KMT2A | |
| SCHEMBL4458935 | 0.83 | NPSR1 (0.47) | NPSR1ATMTDP1L3MBTL1KMT2A | |
| SCHEMBL398536 | 0.80 | NPSR1 (0.44) | NPSR1ATMTDP1L3MBTL1PTGIR | |
| SCHEMBL3424139 | 0.79 | SMN1; SMN2 (0.44) | NPSR1ATMTDP1L3MBTL1KMT2A | |
| SCHEMBL748812 | 0.78 | NPSR1 (0.73) | NPSR1ATMTDP1L3MBTL1PTGIR | |
| SCHEMBL27960846 | 0.78 | NPSR1 (0.73) | NPSR1ATMTDP1L3MBTL1PTGIR | |
| SCHEMBL402771 | 0.77 | NPSR1 (0.41) | NPSR1ATMTDP1L3MBTL1PTGIR | |
| SCHEMBL17674048 | 0.73 | DHFR (0.42) | KMT2AHTTMEN1 | |
| SCHEMBL4657473 | 0.73 | ALDH1A1 (0.58) | NPSR1L3MBTL1KMT2AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962830-A2 | AZAINDOLE INHIBITORS OF AURORA KINASES | SmithKline Beecham Corporation (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007076348-A2 | AZAINDOLE INHIBITORS OF AURORA KINASES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |