SCHEMBL5142489

SCHEMBL5142489

N#Cc1c[nH]c(C(=O)Nc2ccc(C3CCN(CCO)CC3)cc2C2=CCCCC2)n1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 18/20 0.75
KIT P10721 8/20 0.75
CYP3A4 P08684 8/20 0.64
NTRK1 P04629 4/20 0.64
LCK P06239 4/20 0.64
AXL P30530 4/20 0.64
FLT3 P36888 4/20 0.64
CYP2C19 P33261 5/20 0.57
KCNH2 Q12809 1/20 0.57
BMPR1B O00238 2/20 0.56
PLK4 O00444 2/20 0.56
STK25 O00506 2/20 0.56
RIOK3 O14730 2/20 0.56
CHEK1 O14757 2/20 0.56
GAK O14976 2/20 0.56
DCLK1 O15075 2/20 0.56
MUSK O15146 2/20 0.56
EPHB6 O15197 2/20 0.56
PDPK1 O15530 2/20 0.56
MAP3K13 O43283 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL4983287 0.95 CSF1R (0.68) CSF1RKITCYP3A4NTRK1LCK
SCHEMBL13105559 0.93 CSF1R (0.75) CSF1RKITCYP3A4NTRK1LCK
SCHEMBL13096399 0.93 CSF1R (0.75) CSF1RKITCYP3A4NTRK1LCK
SCHEMBL14542959 0.92 CSF1R (0.62) CSF1RKITCYP3A4NTRK1LCK
SCHEMBL2942044 0.91 CSF1R (0.75) CSF1RKITCYP3A4NTRK1LCK
SCHEMBL4986321 0.91 CSF1R (0.76) CSF1RKITCYP3A4NTRK1LCK
SCHEMBL13105790 0.90 CSF1R (0.75) CSF1RKITCYP3A4NTRK1LCK
SCHEMBL14516350 0.89 CSF1R (0.69) CSF1RKITCYP3A4NTRK1LCK
SCHEMBL5181727 0.89 CSF1R (0.75) CSF1RKITCYP3A4NTRK1LCK
SCHEMBL2940010 0.88 CSF1R (0.64) CSF1RKITCYP3A4NTRK1LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9526731-B2 Method of inhibiting C-KIT kinase JANSSEN PHARMACEUTICA NV (BE) 2016-12-27 US disclosed
EP-1807077-B1 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA NV (BE) 2016-11-23 EP disclosed
US-20150094520-A1 METHOD OF INHIBITING C-KIT KINASE JANSSEN PHARMACEUTICA NV (BE) 2015-04-02 US disclosed
US-8933091-B2 Method of inhibiting C-KIT kinase JANSSEN PHARMACEUTICA NV (BE) 2015-01-13 US disclosed
US-8557847-B2 Synergistic modulation of FLT3 kinase using a FLT3 inhibitor and a farnesyl transferase inhibitor JANSSEN PHARMACEUTICA, N.V. (BE) 2013-10-15 US disclosed
US-20100256148-A1 USE OF CFMS INHIBITOR FOR TREATING OR PREVENTING BONE CANCER AND THE BONE LOSS AND BONE PAIN ASSOCIATED WITH BONE CANCER JANSSEN PHARMACEUTICA NV (BE) 2010-10-07 US disclosed
US-7795279-B2 Method of inhibiting FLT3 kinase JANSSEN PHARMACEUTICA NV (BE) 2010-09-14 US disclosed
US-7662837-B2 4-cyano-1H-imidazole-2-carboxylic acid {2-cyclohex-1-enyl-4-[1-(2-dimethylamino-acetyl)-piperidin-4-yl]-phenyl}-amide; protein tyrosine kinase inhibitor; autoimmune diseases, antiinflammatory, anticarcinogenic agent JANSSEN PHARMACEUTICA N.V. (BE) 2010-02-16 US disclosed
US-7645755-B2 Inhibitors of c-fms kinase JANSSEN PHARMACEUTICAL N.V. (BE) 2010-01-12 US disclosed
US-20090197913-A1 SYNERGISTIC MODULATION OF FLT3 KINASE USING A FLT3 INHIBITOR AND A FARNESYL TRANSFERASE INHIBITOR BAUMANN CHRISTIAN ANDREW 2009-08-06 US disclosed
WO-2009058801-A1 USE OF CFMS INHIBITOR FOR TREATING OR PREVENTING BONE CANCER AND THE BONE LOSS AND BONE PAIN ASSOCIATED WITH BONE CANCER JANSSEN PHARMACEUTICA, N.V. (BE) 2009-05-07 WO disclosed
EP-1898912-A1 SYNERGISTIC MODULATION OF FLT3 KINASE USING A FLT3 INHIBITOR AND A FARNESYL TRANSFERASE INHIBITOR JANSSEN PHARMACEUTICA N.V. (BE) 2008-03-19 EP disclosed
US-20080051402-A1 METHOD OF INHIBITING C-KIT KINASE JANSSEN PHARMACEUTICA NV (BE) 2008-02-28 US disclosed
WO-2007124369-A2 METHOD OF INHIBITING C KIT KINASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-11-01 WO disclosed
US-20070149572-A1 METHOD OF INHIBITING FLT3 KINASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-06-28 US disclosed
WO-2007048088-A2 METHOD OF INHIBITING FLT3 KINASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-04-26 WO disclosed
WO-2006138155-A1 SYNERGISTIC MODULATION OF FLT3 KINASE USING A FLT3 INHIBITOR AND A FARNESYL TRANSFERASE INHIBITOR JANSSEN PHARMACEUTICA N.V. (BE) 2006-12-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100256148-A1 USE OF CFMS INHIBITOR FOR TREATING OR PREVENTING BONE CANCER AND THE BONE LOSS AND BONE PAIN ASSOCIATED WITH BONE CANCER SOST, CALCB, CALCA CSF1R 304/4885KIT 873/4885CYP3A4 4421/4885
US-20080051402-A1 METHOD OF INHIBITING C-KIT KINASE KIT, CHUK, MAP3K13 CSF1R 2973/4885KIT 1/4885CYP3A4 4130/4885
US-20090197913-A1 SYNERGISTIC MODULATION OF FLT3 KINASE USING A FLT3 INHIBITOR AND A FARNESYL TRANSFERASE INHIBITOR FLT3, MCL1, CSF1R CSF1R 3/4885KIT 70/4885CYP3A4 2047/4885
US-20070149572-A1 METHOD OF INHIBITING FLT3 KINASE FLT3, PLK1, PHKG1 CSF1R 149/4885KIT 192/4885CYP3A4 3994/4885
US-20150094520-A1 METHOD OF INHIBITING C-KIT KINASE KIT, CHUK, MAP3K13 CSF1R 2973/4885KIT 1/4885CYP3A4 4130/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.