Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MGAM | O43451 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | SI | P14410 | 1/20 | 0.31 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.31 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5804056 | 0.86 | ALDH1A1 (0.40) | ALDH1A1TSHRLMNAHSD17B10MEN1 | |
| SCHEMBL9023602 | 0.81 | ALDH1A1 (0.39) | ALDH1A1TSHRGLO1LMNAHSD17B10 | |
| SCHEMBL717299 | 0.78 | ALDH1A1 (0.40) | ALDH1A1TSHRNPSR1GLO1LMNA | |
| SCHEMBL20184104 | 0.75 | CYP1A2 (0.35) | ALDH1A1TSHRLMNAHSD17B10MEN1 | |
| SCHEMBL5141898 | 0.75 | GAA (0.47) | ALDH1A1TSHRLMNAKMT2ATDP1 | |
| SCHEMBL4773196 | 0.75 | TDP1 (0.38) | ALDH1A1TSHRNPSR1GLO1LMNA | |
| SCHEMBL10510357 | 0.74 | ALDH1A1 (0.33) | ALDH1A1TSHRLMNAHSD17B10MEN1 | |
| SCHEMBL23043980 | 0.74 | ALDH1A1 (0.40) | ALDH1A1TSHRLMNAHSD17B10MEN1 | |
| SCHEMBL5146402 | 0.73 | TDP1 (0.37) | ALDH1A1TSHRNPSR1GLO1LMNA | |
| SCHEMBL25181738 | 0.73 | MGAM (0.43) | ALDH1A1TSHRNPSR1GLO1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7301031-B2 | Methods for producing hydroxy amino acids, esters, and derivatives thereof | BIOCATALYTICS, INC. (US) | 2007-11-27 | — | — | US | disclosed |
| US-7081535-B2 | Hydroxy-amino acids | BIOCATALYTICS, INC. (US) | 2006-07-25 | — | — | US | disclosed |
| US-20050192439-A1 | Methods for producing hydroxy amino acids, esters, and derivatives thereof | CODEXIS, INC. | 2005-09-01 | — | — | US | disclosed |
| US-20050100993-A1 | Methods for producing hydroxy amino acids and derivatives thereof | BIOCATALYTICS, INC. | 2005-05-12 | — | — | US | disclosed |
| US-6833471-B2 | Contacting beta-ketodiester having ketone and two esters with a ketoreductase under conditions permitting reduction of ketone to alcohol, regioselectively hydrolyzing one of ester groups to acid, converting acid or ester to amine | BIOCATALYTICS, INC. | 2004-12-21 | — | — | US | disclosed |
| US-20040053377-A1 | Methods for producing hydroxy amino acids and derivatives thereof | CODEXIS, INC. | 2004-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053377-A1 | Methods for producing hydroxy amino acids and derivatives thereof | HMGCR, HSD17B12, BCKDK | ALDH1A1 514/4885TSHR 2569/4885NPSR1 2146/4885 |
| US-20050100993-A1 | Methods for producing hydroxy amino acids and derivatives thereof | ALDH7A1, BCKDK, HSD17B12 | ALDH1A1 130/4885TSHR 3214/4885NPSR1 1943/4885 |
| US-20050192439-A1 | Methods for producing hydroxy amino acids, esters, and derivatives thereof | ALDH7A1, BCKDK, ADH5 | ALDH1A1 135/4885TSHR 2706/4885NPSR1 1432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.