Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 2/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7599990 | 0.80 | P2RX7 (0.48) | ALDH1A1P2RX7HDAC1 | |
| SCHEMBL8833419 | 0.77 | ESR1 (0.46) | GLSESR1ACP3ALDH1A1NR3C2 | |
| SCHEMBL8614640 | 0.76 | PTGS2 (0.46) | MAPT | |
| SCHEMBL15695548 | 0.75 | ESR1 (0.45) | GLSESR1ACP3ALDH1A1CXCL8 | |
| SCHEMBL15641407 | 0.75 | PTGS2 (0.48) | GLSESR1ACP3ALDH1A1KDM4E | |
| SCHEMBL30717242 | 0.75 | PTGS2 (0.48) | GLSESR1ACP3ALDH1A1KDM4E | |
| SCHEMBL362699 | 0.75 | PTGS2 (0.48) | GLSESR1ACP3ALDH1A1KDM4E | |
| SCHEMBL363983 | 0.74 | TSHR (0.48) | GLSESR1ALDH1A1MEN1LMNA | |
| SCHEMBL10996273 | 0.74 | GLS (0.44) | GLSALDH1A1HDAC1NR3C2KMT2A | |
| SCHEMBL8820174 | 0.73 | ESR1 (0.43) | GLSESR1ACP3ALDH1A1CXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463465-A4 | BIOACTIVE SPINAL IMPLANTS AND METHOD OF MANUFACTURE THEREOF | VITA SPECIAL PURPOSE CORP (US) | 2007-10-03 | — | — | EP | disclosed |
| EP-1463465-A1 | BIOACTIVE SPINAL IMPLANTS AND METHOD OF MANUFACTURE THEREOF | Vita Special Purpose Corporation (US) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003053290-A1 | BIOACTIVE SPINAL IMPLANTS AND METHOD OF MANUFACTURE THEREOF | VITA SPECIAL PURPOSE CORPORATION (US) | 2003-07-03 | — | — | WO | disclosed |