Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.36 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | TLR2 | O60603 | 1/20 | 0.33 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17748162 | 0.87 | ALDH1A1 (0.42) | ALDH1A1LMNAMAPTKMT2AEHMT2 | |
| SCHEMBL17752518 | 0.87 | ALDH1A1 (0.42) | ALDH1A1LMNAMAPTKMT2AEHMT2 | |
| SCHEMBL12575473 | 0.83 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTKMT2AEHMT2 | |
| SCHEMBL906678 | 0.83 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTKMT2AEHMT2 | |
| SCHEMBL12575508 | 0.82 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPTKMT2AEHMT2 | |
| SCHEMBL12575507 | 0.82 | LMNA (0.39) | ALDH1A1LMNAMAPTKMT2AEHMT2 | |
| SCHEMBL17451463 | 0.81 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTKMT2AEHMT2 | |
| SCHEMBL15907906 | 0.81 | ALDH1A1 (0.41) | ALDH1A1LMNAMAPTKMT2AEHMT2 | |
| SCHEMBL9885498 | 0.81 | ALDH1A1 (0.33) | ALDH1A1LMNAKMT2AHPGDHDAC1 | |
| SCHEMBL10326593 | 0.81 | EHMT2 (0.55) | ALDH1A1LMNAMAPTKMT2AEHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463558-B1 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | IMMUNOGEN INC (US) | 2012-06-06 | — | — | EP | disclosed |
| EP-1463558-A4 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | IMMUNOGEN INC (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1463558-A2 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | Immunogen, Inc. (US) | 2004-10-06 | — | — | EP | disclosed |
| US-6716821-B2 | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same | IMMUNOGEN INC. | 2004-04-06 | — | — | US | disclosed |
| US-20040001838-A1 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | IMMUNOGEN, INC. | 2004-01-01 | — | — | US | disclosed |
| WO-2003068144-A2 | CYTOTOXIC AGENTS | IMMUNOGEN, INC. (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040001838-A1 | CYTOTOXIC AGENTS BEARING A REACTIVE POLYETHYLENE GLYCOL MOIETY, CYTOTOXIC CONJUGATES COMPRISING POLYETHYLENE GLYCOL LINKING GROUPS, AND METHODS OF MAKING AND USING THE SAME | MCL1, CD47, BAX | ALDH1A1 2607/4885LMNA 1897/4885MAPT 3489/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.