Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 9/20 | 0.56 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.56 |
| ▸ | TYR | P14679 | 1/20 | 0.56 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 1/20 | 0.44 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.44 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ME2 | P23368 | 1/20 | 0.41 |
| ▸ | ME1 | P48163 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13078747 | 0.79 | ERN1 (0.60) | ERN1TRIM24TYRTRIM33ALDH1A1 | |
| SCHEMBL16096807 | 0.78 | ERN1 (0.48) | ERN1TRIM24TRIM33HDAC4HDAC2 | |
| SCHEMBL29399003 | 0.77 | ERN1 (0.74) | ERN1TRIM24TYRTRIM33HDAC4 | |
| SCHEMBL19798735 | 0.77 | ERN1 (0.74) | ERN1TRIM24TYRTRIM33HDAC4 | |
| SCHEMBL1005010 | 0.72 | CA1 (0.61) | ERN1TRIM24TYRTRIM33ALDH1A1 | |
| SCHEMBL133876 | 0.72 | TYR (1.00) | ERN1TRIM24TYRTRIM33ALDH1A1 | |
| SCHEMBL29459651 | 0.72 | CA1 (0.61) | ERN1TRIM24TYRTRIM33ALDH1A1 | |
| SCHEMBL120412 | 0.72 | ERN1 (1.00) | ERN1TRIM24TYRTRIM33ALDH1A1 | |
| SCHEMBL29559365 | 0.72 | ERN1 (1.00) | ERN1TRIM24TYRTRIM33ALDH1A1 | |
| SCHEMBL28803580 | 0.71 | ALDH1A1 (0.53) | ERN1TRIM24TYRTRIM33ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1450812-A4 | USE OF BENZOPYRANONES FOR TREATING OR PREVENTING A PRIMARY BRAIN CANCER OR A BRAIN METASTASIS | SIGNAL PHARM INC (US) | 2007-03-28 | — | — | EP | disclosed |
| US-7148252-B2 | Use of benzopyranones for treating or preventing a primary brain cancer or a brain metastasis | SIGNAL PHARMACEUTICALS, LLC (US) | 2006-12-12 | — | — | US | disclosed |
| EP-1450812-A2 | USE OF BENZOPYRANONES FOR TREATING OR PREVENTING A PRIMARY BRAIN CANCER OR A BRAIN METASTASIS | Signal Pharmaceuticals, Inc. (US) | 2004-09-01 | — | — | EP | disclosed |
| US-20030149025-A1 | Use of benzopyranones for treating or preventing a primary brain cancer or a brain metastasis | SIGNAL PHARMACEUTICALS, INC. | 2003-08-07 | — | — | US | disclosed |
| WO-2003028652-A2 | USE OF BENZOPYRANONES FOR TREATING OR PREVENTING A PRIMARY BRAIN CANCER OR A BRAIN METASTASIS | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030149025-A1 | Use of benzopyranones for treating or preventing a primary brain cancer or a brain metastasis | RB1, FOXK1, SKP1 | ERN1 3362/4885TRIM24 4294/4885TYR 1417/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.