Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SNCA | P37840 | 2/20 | 0.38 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13733324 | 0.85 | APP (0.58) | APPALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL27593766 | 0.80 | CYP1A2 (0.44) | KMT2ASIGMAR1 | |
| SCHEMBL900444 | 0.73 | APP (0.37) | APPALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL6044185 | 0.72 | APP (0.49) | APPALDH1A1TERTMAPK1TDP1 | |
| SCHEMBL13487155 | 0.70 | CYP1A2 (0.57) | APPALDH1A1TERTMAPK1TDP1 | |
| SCHEMBL30830203 | 0.70 | APP (0.66) | APPALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL29235054 | 0.70 | APP (0.66) | APPALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL29235056 | 0.70 | APP (0.66) | APPALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL12566471 | 0.69 | TERT (0.64) | APPALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL14311184 | 0.69 | APP (0.45) | APPALDH1A1TERTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1624900-A4 | METHODS FOR BINDING AGENTS TO BETA-AMYLOID PLAQUES | UNIV CALIFORNIA (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1624900-A2 | METHODS FOR BINDING AGENTS TO BETA-AMYLOID PLAQUES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-02-15 | — | — | EP | disclosed |
| WO-2005040337-A2 | METHODS FOR BINDING AGENTS TO β-AMYLOID PLAQUES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-05-06 | — | — | WO | disclosed |