Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 3/20 | 0.35 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5281249 | 1.00 | PTGS1 (0.48) | PTGS1ALDH1A1MAPTSLC1A3SLC1A2 | |
| SCHEMBL20663432 | 0.84 | ALDH1A1 (0.40) | PTGS1ALDH1A1MAPTSLC1A3SLC1A2 | |
| SCHEMBL20192732 | 0.83 | ALDH1A1 (0.39) | PTGS1ALDH1A1MAPTSLC1A3SLC1A2 | |
| SCHEMBL18924801 | 0.81 | ALDH1A1 (0.42) | PTGS1ALDH1A1MAPTSLC1A3SLC1A2 | |
| SCHEMBL20192905 | 0.81 | PTGS1 (0.47) | PTGS1ALDH1A1MAPTSLC1A3SLC1A2 | |
| SCHEMBL23170050 | 0.81 | ALDH1A1 (0.38) | PTGS1ALDH1A1MAPTSLC1A3SLC1A2 | |
| SCHEMBL7872141 | 0.80 | ALDH1A1 (0.44) | PTGS1ALDH1A1MAPTSLC1A3SLC1A2 | |
| SCHEMBL27777133 | 0.80 | ALDH1A1 (0.44) | PTGS1ALDH1A1MAPTSLC1A3SLC1A2 | |
| SCHEMBL22508721 | 0.80 | PTGS1 (0.50) | PTGS1ALDH1A1MAPTSLC1A3SLC1A2 | |
| SCHEMBL5288950 | 0.77 | ALDH1A1 (0.52) | PTGS1ALDH1A1MAPTSLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551420-A4 | ARYL PHOSPHATE DERIVATIVES WITH SELECTIVE ACTIVITY AGAINST ADENOVIRUS AND HIV | PARKER HUGHES INST (US) | 2007-11-21 | — | — | EP | disclosed |
| EP-1594976-A4 | ARYL PHOSPHATE DERIVATIVES OF d4T HAVING ACTIVITY AGAINST RESISTANT HIV STRAINS | PARKER HUGHES INST (US) | 2007-11-07 | — | — | EP | disclosed |
| US-20070015733-A1 | Aryl Phosphate Derivatives of d4T having Activity Against Resistant HIV Strains | PARKER HUGHES INSTITUTE (US) | 2007-01-18 | — | — | US | disclosed |
| US-7144874-B2 | Aryl phosphate derivatives of d4T having activity against resistant HIV strains | PARKER HUGHES INSTITUTE (US) | 2006-12-05 | — | — | US | disclosed |
| EP-1594976-A2 | ARYL PHOSPHATE DERIVATIVES OF d4T HAVING ACTIVITY AGAINST RESISTANT HIV STRAINS | Parker Hughes Institute (US) | 2005-11-16 | — | — | EP | disclosed |
| EP-1551420-A1 | ARYL PHOSPHATE DERIVATIVES WITH SELECTIVE ACTIVITY AGAINST ADENOVIRUS AND HIV | Parker Hughes Institute (US) | 2005-07-13 | — | — | EP | disclosed |
| US-20050143339-A1 | Aryl phosphate derivatives of D4T with potent anti-viral activity | PARKER HUGHES INSTITUTE (US) | 2005-06-30 | — | — | US | disclosed |
| US-6825177-B2 | 2',3'-DIDEHYDRO-3'-DEOXYTHYMIDINE (D4T); EXTENDING THE ELIMINATION HALF-LIFE OF D4T METABOLITE IN A MAMMAL ADMINISTERING SAID DERIVATIVE; TREATING HUMAN IMMUNODEFICIENCY VIRUS (HIV) | PARKER HUGHES INSTITUTE | 2004-11-30 | — | — | US | disclosed |
| WO-2004040002-A2 | ARYL PHOSPHATE DERIVATIVES OF d4T HAVING ACTIVITY AGAINST RESISTANT HIV STRAINS | PARKER HUGHES INSTITUTE (US) | 2004-05-13 | — | — | WO | disclosed |
| US-20040087549-A1 | Aryl phosphate derivatives of d4T having activity against resistant HIV strains | UCKUN, FATIH M. | 2004-05-06 | — | — | US | disclosed |
| US-20040077607-A1 | Aryl phosphate derivatives of d4T with potent anti-viral activity against hemorrhagic fever viruses | PARKER HUGHES INSTITUTE | 2004-04-22 | — | — | US | disclosed |
| US-20030236218-A1 | Aryl phosphate derivatives of d4T with selective activity against adenovirus and HIV | PARKER HUGHES INSTITUTE | 2003-12-25 | — | — | US | disclosed |
| WO-2003105863-A1 | ARYL PHOSPHATE DERIVATIVES WITH SELECTIVE ACTIVITY AGAINST ADENOVIRUS AND HIV | PARKER HUGHES INSTITUTE (US) | 2003-12-24 | — | — | WO | disclosed |
| US-6482805-B2 | AZT derivatives exhibiting spermicidal and anti-viral activity | PARKER HUGHES INSTITUTE | 2002-11-19 | — | — | US | disclosed |
| US-6465641-B1 | METHOD INCLUDES CONTACTING PHOSPHOROUS OXYCHLORIDE WITH A HALOPHENYL MOIETY FOLLOWED BY CONTACTING THE RESULTING HALOPHENYLPHOSPHORODICHLORIDATE WITH A CARBOXY-PROTECTED AMINO ACID AND FINALLY CONTACTING THE RESULTING HALOPHENYLCARBOXY | PARKER HUGHES INSTITUTE | 2002-10-15 | — | — | US | disclosed |
| US-20020137726-A1 | Aryl phosphate derivatives of D4T with potent anti-viral activity | PARKER HUGHES INSTITUTE | 2002-09-26 | — | — | US | disclosed |
| US-20020025922-A1 | AZT derivatives exhibiting spermicidal and anti-viral activity | UCKUN, FATIH M. | 2002-02-28 | — | — | US | disclosed |
| WO-2000056750-A1 | ONE POT SYNTHESIS OF 5'-HYDROXY PHOSPHORYLATED NUCLEOSIDE DERIVATIVES, AND COMPOUNDS FORMED THEREBY | PARKER HUGHES INSTITUTE (US) | 2000-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087549-A1 | Aryl phosphate derivatives of d4T having activity against resistant HIV strains | TYMP, PNP, APRT | PTGS1 3776/4885ALDH1A1 1280/4885MAPT 981/4885 |
| US-20040077607-A1 | Aryl phosphate derivatives of d4T with potent anti-viral activity against hemorrhagic fever viruses | PNP, GNPAT, AASDHPPT | PTGS1 3753/4885ALDH1A1 1584/4885MAPT 652/4885 |
| US-20070015733-A1 | Aryl Phosphate Derivatives of d4T having Activity Against Resistant HIV Strains | TYMP, PNP, APRT | PTGS1 3776/4885ALDH1A1 1280/4885MAPT 981/4885 |
| US-20020025922-A1 | AZT derivatives exhibiting spermicidal and anti-viral activity | TYMP, DUT, UNG | PTGS1 4322/4885ALDH1A1 919/4885MAPT 2369/4885 |
| US-20020137726-A1 | Aryl phosphate derivatives of D4T with potent anti-viral activity | TYMP, PNP, GART | PTGS1 3352/4885ALDH1A1 1996/4885MAPT 1302/4885 |
| US-20030236218-A1 | Aryl phosphate derivatives of d4T with selective activity against adenovirus and HIV | APRT, AASDHPPT, GNPAT | PTGS1 4601/4885ALDH1A1 1540/4885MAPT 182/4885 |
| US-20050143339-A1 | Aryl phosphate derivatives of D4T with potent anti-viral activity | TYMP, PNP, APRT | PTGS1 3241/4885ALDH1A1 1923/4885MAPT 1122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.