SCHEMBL5144738

SCHEMBL5144738

CCCc1nc2c(N)nc3cc(Br)ccc3c2s1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 20/20 0.68
TLR7 Q9NYK1 15/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1528112 0.90 TLR8 (0.77) TLR8TLR7
SCHEMBL5146563 0.86 TLR8 (0.51) TLR8TLR7
SCHEMBL1527827 0.86 TLR8 (0.70) TLR8TLR7
SCHEMBL2400748 0.85 TLR8 (0.68) TLR8TLR7
SCHEMBL1528150 0.85 TLR8 (0.68) TLR8TLR7
SCHEMBL1528096 0.85 TLR8 (0.68) TLR8TLR7
SCHEMBL5146603 0.84 TLR8 (0.49) TLR8TLR7
SCHEMBL5144810 0.84 TLR7 (0.50) TLR8TLR7
SCHEMBL1528031 0.82 TLR8 (0.65) TLR8TLR7
SCHEMBL5146432 0.82 TLR8 (0.55) TLR8TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3793613-B1 IMMUNOCONJUGATES BOLT BIOTHERAPEUTICS INC (US) 2025-01-01 EP disclosed
US-20210154316-A1 Immunoconjugates BOLT BIOTHERAPEUTICS, INC. (US) 2021-05-27 US disclosed
EP-3793613-A1 IMMUNOCONJUGATES Bolt Biotherapeutics, Inc. (US) 2021-03-24 EP disclosed
CN-112153988-A Immunoconjugates 博尔特生物治疗药物有限公司 2020-12-29 CN disclosed
US-20070259907-A1 ARYL AND ARYLALKYLENYL SUBSTITUTED THIAZOLOQUINOLINES AND THIAZOLONAPHTHYRIDINES 3M INNOVATIVE PROPERTIES COMPANY 2007-11-08 US disclosed
WO-2006093514-A2 ARYL AND ARYLALKYLENYL SUBSTITUTED THIAZOLOQUINOLINES AND THIAZOLONAPHTHYRIDINES 3M INNOVATIVE PROPERTIES COMPANY (US) 2006-09-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210154316-A1 Immunoconjugates FCGR3B, FCGR2A, FCGR1A TLR8 54/4885TLR7 105/4885
US-20070259907-A1 ARYL AND ARYLALKYLENYL SUBSTITUTED THIAZOLOQUINOLINES AND THIAZOLONAPHTHYRIDINES IL2, TSLP, IFNG TLR8 86/4885TLR7 39/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.