Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GPX4 | P36969 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3744394 | 0.92 | SIGMAR1 (0.43) | SIGMAR1ALDH1A1CYP3A4 | |
| SCHEMBL11191152 | 0.84 | NPC1 (0.41) | NPC1RAB9APAX8JAK2KCNH2 | |
| SCHEMBL10598512 | 0.82 | NPC1 (0.56) | NPC1RAB9APAX8JAK2ALDH1A1 | |
| SCHEMBL8028077 | 0.81 | NPC1 (0.42) | NPC1RAB9APAX8JAK2ALDH1A1 | |
| SCHEMBL10353146 | 0.80 | NPC1 (0.38) | NPC1RAB9APAX8JAK2KCNH2 | |
| SCHEMBL4282388 | 0.79 | NPC1 (0.38) | NPC1RAB9APAX8JAK2ALDH1A1 | |
| SCHEMBL18741214 | 0.78 | CYP3A4 (0.41) | CNR2SIGMAR1TP53CYP3A4 | |
| SCHEMBL4983976 | 0.77 | MEN1 (0.50) | NPC1RAB9APAX8JAK2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL8194065 | 0.76 | GRIN2D (0.49) | NPC1RAB9APAX8JAK2ALDH1A1 | |
| SCHEMBL5200019 | 0.76 | LMNA (0.40) | NPC1RAB9APAX8JAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633368-A4 | FOAMABLE PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING A DISORDER | STIEFEL LABORATORIES (US) | 2007-03-14 | — | — | EP | disclosed |
| EP-1633368-A2 | FOAMABLE PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING A DISORDER | STIEFEL LABORATORIES, INC. (US) | 2006-03-15 | — | — | EP | disclosed |
| WO-2004105702-A2 | FOAMABLE PHARMACEUTICAL COMPOSITIONS AND METHODS FOR TREATING A DISORDER | STIEFEL LABORATORIES, INC. (US) | 2004-12-09 | — | — | WO | disclosed |