Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.35 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.35 |
| ▸ | MLYCD | O95822 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GPX4 | P36969 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10598512 | 0.80 | NPC1 (0.56) | NPC1RAB9APAX8JAK2GRIN2D | |
| SCHEMBL5144850 | 0.79 | NPC1 (0.46) | NPC1RAB9APAX8JAK2ALDH1A1 | |
| SCHEMBL8028077 | 0.76 | NPC1 (0.42) | NPC1RAB9APAX8JAK2GRIN2D | |
| SCHEMBL4983976 | 0.74 | MEN1 (0.50) | NPC1RAB9APAX8JAK2GRIN2D | |
| Hydrochloric Acid SCHEMBL8194065 | 0.73 | GRIN2D (0.49) | NPC1RAB9APAX8JAK2GRIN2D | |
| Hydrochloric Acid SCHEMBL7571060 | 0.71 | ALOX5 (0.45) | NPC1RAB9APAX8JAK2GRIN2D | |
| SCHEMBL10597779 | 0.70 | TRPV1 (0.44) | NPC1RAB9APAX8JAK2GRIN2D | |
| SCHEMBL3744394 | 0.69 | SIGMAR1 (0.43) | ALDH1A1 | |
| SCHEMBL10824119 | 0.67 | MEN1 (0.53) | NPC1RAB9APAX8JAK2GRIN2D | |
| SCHEMBL8802180 | 0.66 | ESR1 (0.49) | ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090036704-A1 | Process for Preparing 4-Pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-02-05 | — | — | US | claimed |
| US-7449594-B2 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-11-11 | — | — | US | claimed |
| US-20070106094-A1 | Process For Preparing 4-Pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-10 | — | — | US | claimed |
| US-7126026-B2 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-10-24 | — | — | US | claimed |
| US-20050131070-A1 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-06-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036704-A1 | Process for Preparing 4-Pentafluorosulfanylbenzoylguanidines | NHERF1, SLC9A1, SLC5A1 | NPC1 469/4885RAB9A 376/4885PAX8 3452/4885 |
| US-20050131070-A1 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | NHERF1, SLC9A1, SLC5A1 | NPC1 469/4885RAB9A 376/4885PAX8 3452/4885 |
| US-20070106094-A1 | Process For Preparing 4-Pentafluorosulfanylbenzoylguanidines | PAH, NCEH1, PNMT | NPC1 333/4885RAB9A 887/4885PAX8 4034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.