Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ILK | Q13418 | 12/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29741739 | 0.81 | ILK (0.56) | CYP3A4CYP1A2CYP2C19ILKAXL | |
| SCHEMBL2678487 | 0.81 | ILK (0.56) | CYP3A4CYP1A2CYP2C19ILKAXL | |
| SCHEMBL2552313 | 0.78 | CYP3A4 (0.53) | CYP3A4CYP1A2CYP2C19ILKPIK3CD | |
| SCHEMBL31114638 | 0.78 | CYP3A4 (0.59) | CYP3A4CYP1A2CYP2C19PIK3CDPIP5K1C | |
| SCHEMBL9722790 | 0.78 | CYP3A4 (0.59) | CYP3A4CYP1A2CYP2C19PIK3CDPIP5K1C | |
| SCHEMBL371554 | 0.77 | FGFR2 (0.48) | AXL | |
| SCHEMBL20525612 | 0.72 | ILK (0.38) | CYP3A4CYP1A2CYP2C19ILKALDH1A1 | |
| SCHEMBL21186003 | 0.71 | TP53 (0.59) | CYP3A4CYP1A2CYP2C19PIK3CAPI4KA | |
| SCHEMBL8435128 | 0.71 | CYP3A4 (0.55) | CYP3A4CYP1A2CYP2C19ILKPIK3CD | |
| SCHEMBL21186004 | 0.71 | AXL (0.49) | CYP3A4CYP1A2CYP2C19ILKPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174947-B2 | c-Met modulators and methods of use | Exelixus, Inc. (US) | 2015-11-03 | — | — | US | disclosed |
| US-20070054928-A1 | c-Met modulators and methods of use | EXELIXIS, INC. (US) | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054928-A1 | c-Met modulators and methods of use | FLT4, FLT1, MET | CYP3A4 1264/4885CYP1A2 3232/4885CYP2C19 2449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.