Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.49 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.48 |
| ▸ | PI4KA | P42356 | 3/20 | 0.48 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | PIP5K1C | O60331 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31114638 | 1.00 | CYP3A4 (0.59) | CYP3A4CYP1A2CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL31081320 | 0.89 | CYP3A4 (0.49) | CYP3A4CYP1A2CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL9722731 | 0.89 | CYP3A4 (0.56) | CYP3A4CYP1A2CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL8435128 | 0.87 | CYP3A4 (0.55) | CYP3A4CYP1A2CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL11685051 | 0.87 | CYP3A4 (0.68) | CYP3A4CYP1A2CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL11336182 | 0.87 | CYP3A4 (0.68) | CYP3A4CYP1A2CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL2678487 | 0.86 | ILK (0.56) | CYP3A4CYP1A2CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL12235989 | 0.86 | CYP3A4 (0.53) | CYP3A4CYP1A2CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL2552313 | 0.86 | CYP3A4 (0.53) | CYP3A4CYP1A2CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL21091211 | 0.86 | CYP3A4 (0.53) | CYP3A4CYP1A2CYP2C19SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200392092-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2020-12-17 | — | — | US | claimed |
| US-10647689-B2 | Apelin receptor agonists and methods of use thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2020-05-12 | — | — | US | claimed |
| US-20180118698-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2018-05-03 | — | — | US | claimed |
| WO-2016176473-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | SANFORD-BURNHAM MEDICAL RESEARC INSTITUTE (US) | 2016-11-03 | — | — | WO | claimed |
| US-20250382273-A1 | BENZOTHIAZOLE ANAOLOGUES AND USE THEREOF AS BOOSTERS OF ANTI TUBERCULOSIS DRUGS | INST NAT SANTE RECH MED (FR) | 2025-12-18 | — | — | US | disclosed |
| WO-2025054238-A1 | MULTI-TARGET DIRECTED LIGANDS FOR ALZHEIMER'S DISEASE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2025-03-13 | — | — | WO | disclosed |
| EP-4460500-A1 | BENZOTHIAZOLE ANAOLOGUES AND USE THEREOF AS BOOSTERS OF ANTI TUBERCULOSIS DRUGS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM (FR) | 2024-11-13 | — | — | EP | disclosed |
| US-20230390259-A1 | PHARMACEUTICAL COMPOSITION COMPRISING PYRIDONE DERIVATIVES | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2023-12-07 | — | — | US | disclosed |
| US-20230339872-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2023-10-26 | — | — | US | disclosed |
| WO-2023131649-A1 | BENZOTHIAZOLE ANAOLOGUES AND USE THEREOF AS BOOSTERS OF ANTI TUBERCULOSIS DRUGS | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2023-07-13 | — | — | WO | disclosed |
| US-20230210966-A1 | EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES WITH POTASSIUM CHANNEL AGONISTS AND THERAPEUTIC USES THEREOF | LION BIOTECHNOLOGIES, INC. | 2023-07-06 | — | — | US | disclosed |
| US-11673873-B2 | Apelin receptor agonists and methods of use thereof | Sanford Burnham Prebys Medical Discovery Institute (US) | 2023-06-13 | — | — | US | disclosed |
| US-4507477-A | CYCLIZATION | RIKER LABORATORIES, INC. (US) | 1985-03-26 | — | — | US | disclosed |
| US-4252716-A | BLUE SHADES | BAYER AKTIENGESELLSCHAFT (DE) | 1981-02-24 | — | — | US | disclosed |
| US-4233214-A | FOR POLYACRYLONITRILE AND ACID-MODIFIED POLYESTERS OR POLYAMIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1980-11-11 | — | — | US | disclosed |
| US-4051084-A | BENZOTHIAZOLE | BAYER AKTIENGESELLSCHAFT (DT) | 1977-09-27 | — | — | US | disclosed |
| US-4039526-A | PRINTING, POLYACRYLONITRILE, POLYESTERS, POLYAMIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-08-02 | — | — | US | disclosed |
| US-4036826-A | Cationic azo dyestuffs with a hydroxyalkylated ammonium group | BAYER AKTIENGESELLSCHAFT (DT) | 1977-07-19 | — | — | US | disclosed |
| US-3991042-A | Basic azo dyestuffs containing a benzthiazole and a tetrahydroquinoline nucleus | BAYER AKTIENGESELLSCHAFT (DT) | 1976-11-09 | — | — | US | disclosed |
| US-3948877-A | POLYACRYLONITRILE, ACID MODIFIED POLYESTERS OR POLYAMIDES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339872-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | APLNR, APMAP, EDNRA | CYP3A4 4277/4885CYP1A2 3488/4885CYP2C19 4273/4885 |
| US-20230210966-A1 | EXPANSION OF TUMOR INFILTRATING LYMPHOCYTES WITH POTASSIUM CHANNEL AGONISTS AND THERAPEUTIC USES THEREOF | KCNN3, KCNK3, KCNA3 | CYP3A4 4471/4885CYP1A2 4617/4885CYP2C19 4611/4885 |
| US-20250382273-A1 | BENZOTHIAZOLE ANAOLOGUES AND USE THEREOF AS BOOSTERS OF ANTI TUBERCULOSIS DRUGS | BBOX1, NDUFB6, NDUFB5 | CYP3A4 343/4885CYP1A2 57/4885CYP2C19 551/4885 |
| US-20200392092-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | APLNR, APMAP, EDNRA | CYP3A4 4277/4885CYP1A2 3488/4885CYP2C19 4273/4885 |
| US-11673873-B2 | Apelin receptor agonists and methods of use thereof | APLNR, APMAP, EDNRA | CYP3A4 4277/4885CYP1A2 3488/4885CYP2C19 4273/4885 |
| US-20230390259-A1 | PHARMACEUTICAL COMPOSITION COMPRISING PYRIDONE DERIVATIVES | PLPBP, PDXK, PIR | CYP3A4 22/4885CYP1A2 174/4885CYP2C19 14/4885 |
| US-20180118698-A1 | APELIN RECEPTOR AGONISTS AND METHODS OF USE THEREOF | APLNR, APMAP, EDNRA | CYP3A4 4277/4885CYP1A2 3488/4885CYP2C19 4273/4885 |
| US-10647689-B2 | Apelin receptor agonists and methods of use thereof | APLNR, APMAP, EDNRA | CYP3A4 4277/4885CYP1A2 3488/4885CYP2C19 4273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.