Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 13/20 | 0.39 |
| ▸ | BRAF | P15056 | 13/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.39 |
| ▸ | ERN1 | O75460 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.39 |
| ▸ | HIPK1 | Q86Z02 | 3/20 | 0.39 |
| ▸ | MAP3K20 | Q9NYL2 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5148381 | 0.94 | BRAF (0.39) | RAF1BRAFMAPK14MAPK8ERN1 | |
| SCHEMBL2979550 | 0.88 | RAF1 (0.37) | RAF1BRAFMAPK14MAPK8ERN1 | |
| SCHEMBL5147485 | 0.84 | RAF1 (0.39) | RAF1BRAFMAPK14MAPK8ERN1 | |
| SCHEMBL5149061 | 0.84 | PLA2G7 (0.38) | PTGS2PLA2G7ALDH1A1 | |
| SCHEMBL5147455 | 0.83 | PLA2G7 (0.37) | PTGS2PLA2G7ALDH1A1 | |
| SCHEMBL2975947 | 0.82 | BRAF (0.36) | RAF1BRAFMAPK14MAPK8ERN1 | |
| SCHEMBL2987614 | 0.82 | ADORA1 (0.36) | RAF1BRAFMAPK14MAPK8ERN1 | |
| SCHEMBL2985533 | 0.81 | ADORA1 (0.36) | RAF1BRAFMAPK14MAPK8ERN1 | |
| SCHEMBL27708078 | 0.81 | RAF1 (0.35) | RAF1BRAFMAPK14MAPK8ERN1 | |
| SCHEMBL5145984 | 0.81 | PLA2G7 (0.41) | RAF1BRAFMAPK14MAPK8ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | claimed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |