Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 11/20 | 0.39 |
| ▸ | BRAF | P15056 | 11/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2976262 | 0.88 | RAF1 (0.37) | RAF1BRAFLMNATSHRTP53 | |
| SCHEMBL5145972 | 0.84 | RAF1 (0.39) | RAF1BRAFMAPK14ERN1ABL1 | |
| SCHEMBL5145833 | 0.82 | ALDH1A1 (0.43) | LMNATSHRMAPK1HTTTP53 | |
| SCHEMBL5149053 | 0.78 | ALDH1A1 (0.41) | LMNATSHRMAPK1HTTTP53 | |
| SCHEMBL2987614 | 0.78 | ADORA1 (0.36) | RAF1BRAFMAPK14RAD52ADORA1 | |
| SCHEMBL5183961 | 0.78 | BRAF (0.34) | RAF1BRAFMAPK14NAMPTERN1 | |
| SCHEMBL5147280 | 0.78 | BRAF (0.37) | RAF1BRAFLMNATSHRMAPK1 | |
| SCHEMBL5147429 | 0.76 | ADORA1 (0.37) | BRAFLMNATSHRMAPK1HTT | |
| SCHEMBL5147484 | 0.76 | SMN1; SMN2 (0.37) | LMNAMAPK1HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5149061 | 0.76 | PLA2G7 (0.38) | NAMPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |