Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CDK7 | P50613 | 2/20 | 0.30 |
| ▸ | CCNH | P51946 | 2/20 | 0.30 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.30 |
| ▸ | GCK | P35557 | 1/20 | 0.30 |
| ▸ | GCKR | Q14397 | 1/20 | 0.30 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CCNK | O75909 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5149061 | 0.89 | PLA2G7 (0.38) | PLA2G7ALDH1A1PTGS2 | |
| SCHEMBL2980447 | 0.88 | PTGS2 (0.31) | PTGS2CDK7CCNHMNAT1GCK | |
| SCHEMBL5145984 | 0.85 | PLA2G7 (0.41) | PLA2G7ALDH1A1 | |
| SCHEMBL5145972 | 0.83 | RAF1 (0.39) | PLA2G7ALDH1A1PTGS2 | |
| SCHEMBL5147484 | 0.81 | SMN1; SMN2 (0.37) | ALDH1A1PTGS2LMNAHTT | |
| SCHEMBL5183961 | 0.80 | BRAF (0.34) | PLA2G7ALDH1A1 | |
| SCHEMBL2988097 | 0.77 | PTGS2 (0.32) | ALDH1A1PTGS2USP2LMNA | |
| SCHEMBL5148381 | 0.76 | BRAF (0.39) | PTGS2 | |
| SCHEMBL5146010 | 0.75 | POLB (0.35) | ALDH1A1ARUSP2LMNAHTT | |
| SCHEMBL5147345 | 0.75 | LMNA (0.37) | PLA2G7ALDH1A1ARUSP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |