Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 5/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 8/20 | 0.36 |
| ▸ | RAF1 | P04049 | 6/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | DKK1 | O94907 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.34 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.34 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2983034 | 0.87 | AKT3 (0.36) | AKT3MKNK1BRAFRAF1IKBKB | |
| SCHEMBL5149061 | 0.87 | PLA2G7 (0.38) | PLA2G7ALDH1A1 | |
| SCHEMBL5147455 | 0.85 | PLA2G7 (0.37) | PLA2G7ALDH1A1 | |
| SCHEMBL5148325 | 0.83 | CDK2 (0.35) | ALDH1A1AKT3BRAFRAF1IKBKB | |
| SCHEMBL5147371 | 0.83 | LOXL2 (0.38) | ALDH1A1AKT3 | |
| SCHEMBL2984806 | 0.81 | ALDH1A1 (0.50) | ALDH1A1BRAFRAF1IKBKB | |
| SCHEMBL5147312 | 0.81 | IKBKB (0.42) | PLA2G7ALDH1A1AKT3MKNK1IKBKB | |
| SCHEMBL5147322 | 0.80 | LOXL2 (0.35) | PLA2G7ALDH1A1AKT3MKNK1BRAF | |
| SCHEMBL5147468 | 0.79 | SMN1; SMN2 (0.40) | PLA2G7ALDH1A1AKT3 | |
| SCHEMBL5147268 | 0.79 | CDK2 (0.37) | PLA2G7ALDH1A1AKT3MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |