SCHEMBL5146249

SCHEMBL5146249

CC(N)C1CCC(C(N)=O)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ROCK2 O75116 5/20 0.46
ROCK1 Q13464 5/20 0.46
PKN2 Q16513 4/20 0.46
RPS6KA5 O75582 3/20 0.46
LRRK2 Q5S007 3/20 0.46
TP53 P04637 2/20 0.46
CYP3A4 P08684 2/20 0.46
PRKD3 O94806 2/20 0.46
CDK1 P06493 2/20 0.46
CDK2 P24941 2/20 0.46
LTK P29376 2/20 0.46
CDK8 P49336 2/20 0.46
PRKX P51817 2/20 0.46
PRKCQ Q04759 2/20 0.46
PRKCD Q05655 2/20 0.46
STK3 Q13188 2/20 0.46
CDC42BPA Q5VT25 2/20 0.46
BRSK1 Q8TDC3 2/20 0.46
CLK4 Q9HAZ1 2/20 0.46
CYP2D6 P10635 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18809334 0.92 ROCK2 (0.42) ROCK2ROCK1PKN2RPS6KA5LRRK2
Pyridine SCHEMBL27499200 0.84 ROCK2 (0.54) ROCK2ROCK1PKN2RPS6KA5LRRK2
SCHEMBL10270878 0.84 ALOX5 (0.43) ROCK2ROCK1PKN2RPS6KA5LRRK2
SCHEMBL8073959 0.84 ALOX5 (0.43) ROCK2ROCK1PKN2RPS6KA5LRRK2
SCHEMBL659048 0.84 ALOX5 (0.43) ROCK2ROCK1PKN2RPS6KA5LRRK2
SCHEMBL5147855 0.82 ROCK2 (0.46) ROCK2ROCK1PKN2RPS6KA5LRRK2
SCHEMBL6483753 0.82 ALOX5 (0.42) ROCK2ROCK1PKN2RPS6KA5LRRK2
SCHEMBL3501685 0.82 ROCK2 (0.46) ROCK2ROCK1PKN2RPS6KA5LRRK2
SCHEMBL9505616 0.82 ROCK2 (0.46) ROCK2ROCK1PKN2RPS6KA5LRRK2
SCHEMBL18560541 0.81 SMN1; SMN2 (0.39) ROCK2ROCK1PKN2RPS6KA5LRRK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-100438910-C Preventives/remedies for liver diseases MITSUBISHI PHARMACEUTICAL CO L (JP) 2008-12-03 CN claimed
CN-1362884-A Preventives/remedies for liver diseases MITSUBISHI PHARMACEUTICAL CO L (JP) 2002-08-07 CN claimed
CN-1358102-A Preventives/remedies for angiostenosis MITSUBISHI PHARMACEUTICAL CO L (JP) 2002-07-10 CN claimed
CN-1287494-A Preventive/remedy for glaucoma SENJI PHARMACEUTICAL CO LTD (JP) 2001-03-14 CN claimed
US-20260049275-A1 INDUCED STEM CELLS UNIV MONASH (AU) 2026-02-19 US disclosed
US-12492372-B2 Induced stem cells MONASH UNIVERSITY (AU) 2025-12-09 US disclosed
US-12060581-B2 Methods and cellular structures MONASH UNIVERSITY (AU) 2024-08-13 US disclosed
US-20240209323-A1 METHODS AND CELLULAR STRUCTURES MONASH UNIVERSITY (AU) 2024-06-27 US disclosed
EP-4251739-A1 INDUCED STEM CELLS Monash University (AU) 2023-10-04 EP disclosed
US-20220403343-A1 METHODS OF REPROGRAMMING A CELL THE UNIVERSITY OF WESTERN AUSTRALIA (AU) 2022-12-22 US disclosed
US-20220389376-A1 Methods for Reprogramming Cells NANTES UNIVERSITE (FR) 2022-12-08 US disclosed
EP-4058565-A1 METHODS FOR REPROGRAMMING CELLS Monash University (AU) 2022-09-21 EP disclosed
CN-1293878-C Preventing or curing agent for eye fatigue and pseudomyopia SENJU PHARMA CO (JP) 2007-01-10 CN disclosed
EP-1539247-A2 ALPHA 5 BETA 1 AND ITS ABILITY TO REGULATE THE CELL SURVIVAL PATHWAY UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) 2005-06-15 EP disclosed
CN-1195547-C Preventive/remedy for glaucoma SENJI PHARMACEUTICAL CO LTD (JP) 2005-04-06 CN disclosed
WO-2004043340-A2 ALPHA 5 BETA 1 AND ITS ABILITY TO REGULATE THE CELL SURVIVAL PATHWAY UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) 2004-05-27 WO disclosed
CN-1494903-A Preventing or curing agent for eye fatigue and pseudomyopia ǧ����ҩ��ʽ���� 2004-05-12 CN disclosed
CN-1362884-A Preventives/remedies for liver diseases MITSUBISHI PHARMACEUTICAL CO L (JP) 2002-08-07 CN disclosed
CN-1358102-A Preventives/remedies for angiostenosis MITSUBISHI PHARMACEUTICAL CO L (JP) 2002-07-10 CN disclosed
CN-1287494-A Preventive/remedy for glaucoma SENJI PHARMACEUTICAL CO LTD (JP) 2001-03-14 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260049275-A1 INDUCED STEM CELLS SALL4, SOX18, LEF1 ROCK2 991/4885ROCK1 345/4885PKN2 2355/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.