SCHEMBL5146381

SCHEMBL5146381

CC(C)(C)[Si](C)(CBr)Oc1ccccc1

nearest known ligand 0.34

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
RIPK1 Q13546 1/20 0.33
CA4 P22748 1/20 0.33
PREP P48147 2/20 0.33
KCNA3 P22001 1/20 0.31
LTA4H P09960 2/20 0.31
TSHR P16473 1/20 0.31
MAPK1 P28482 1/20 0.30
CYP2D6 P10635 1/20 0.30
TP53 P04637 1/20 0.30
MAPT P10636 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19901744 0.79 CA4 (0.37) RIPK1CA4PREPKCNA3LTA4H
SCHEMBL2368966 0.77 PREP (0.45) RIPK1CA4PREPLTA4HTSHR
SCHEMBL31409345 0.77
SCHEMBL3914259 0.75 CA4 (0.39) CA4KCNA3LTA4HTSHR
SCHEMBL3924733 0.75 CA4 (0.39) CA4KCNA3LTA4HTSHR
SCHEMBL707620 0.74 CA4 (0.37) RIPK1CA4KCNA3LTA4HTSHR
Methylamine SCHEMBL7237290 0.74 PREP (0.42) RIPK1CA4PREPLTA4HTSHR
SCHEMBL8983426 0.73 PREP (0.36) RIPK1CA4PREPKCNA3LTA4H
SCHEMBL429409 0.72 CA4 (0.43) RIPK1CA4PREPKCNA3LTA4H
SCHEMBL10951653 0.72 CA4 (0.43) CA4KCNA3LTA4HTSHRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160200689-A1 DELTA OPIOID RECEPTOR AGONIST COMPOUNDS VERSI GROUP LLC (US) 2016-07-14 US disclosed
US-9296707-B2 Delta opioid receptor agonist compounds VERSI GROUP, LLC (US) 2016-03-29 US disclosed
US-8865721-B2 Delta opioid receptor agonist compounds VERSI GROUP, LLC (US) 2014-10-21 US disclosed
US-20140031367-A1 DELTA OPIOID RECEPTOR AGONIST COMPOUNDS VERSI GROUP, LLC (US) 2014-01-30 US disclosed
US-8551998-B2 Delta opioid receptor agonist compounds VERSI GROUP, LLC (US) 2013-10-08 US disclosed
US-20120220601-A1 DELTA OPIOID RECEPTOR AGONIST COMPOUNDS VERSI GROUP, LLC 2012-08-30 US disclosed
US-20070173515-A1 DELTA OPIOID RECEPTOR AGONIST COMPOUNDS MOUNT COOK BIOSCIENCES, INC. (US) 2007-07-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160200689-A1 DELTA OPIOID RECEPTOR AGONIST COMPOUNDS OPRD1, OPRM1, OPRK1 RIPK1 2804/4885CA4 4724/4885PREP 1393/4885
US-20070173515-A1 DELTA OPIOID RECEPTOR AGONIST COMPOUNDS OPRD1, OPRM1, OPRK1 RIPK1 2804/4885CA4 4724/4885PREP 1393/4885
US-20140031367-A1 DELTA OPIOID RECEPTOR AGONIST COMPOUNDS OPRD1, OPRM1, OPRK1 RIPK1 2804/4885CA4 4724/4885PREP 1393/4885
US-20120220601-A1 DELTA OPIOID RECEPTOR AGONIST COMPOUNDS OPRD1, OPRM1, OPRK1 RIPK1 2804/4885CA4 4724/4885PREP 1393/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.