Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5669747 | 0.85 | FADS1 (0.51) | KMT2ANPC1RAB9AMAPTHPGD | |
| SCHEMBL1825721 | 0.83 | ALDH1A1 (0.57) | KDM4EKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL15778764 | 0.79 | FADS1 (0.64) | KMT2AALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL1824116 | 0.74 | RAB9A (0.52) | KDM4EKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL1822638 | 0.74 | STIM1 (0.67) | KDM4EKMT2ANPC1RAB9AMAPT | |
| SCHEMBL1825867 | 0.74 | STIM1 (0.53) | KDM4EKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL1826092 | 0.74 | IL2 (0.58) | KMT2AALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2595461 | 0.73 | HTT (0.63) | KDM4EKMT2AALDH1A1MAPTPOLB | |
| SCHEMBL6815694 | 0.73 | KMT2A (0.64) | KDM4EKMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL6295710 | 0.73 | GAA (0.74) | KDM4EKMT2AALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651232-A4 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2007-06-06 | — | — | EP | disclosed |
| EP-1651232-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | Synta Pharmaceuticals Corporation (US) | 2006-05-03 | — | — | EP | disclosed |
| WO-2005009539-A2 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS, CORP. (US) | 2005-02-03 | — | — | WO | disclosed |