Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 4/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2975764 | 0.84 | AURKA (0.30) | — | |
| SCHEMBL5147395 | 0.84 | CDK2 (0.38) | ALDH1A1SMN1; SMN2HTTPLA2G7KDM4E | |
| SCHEMBL5147369 | 0.81 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5179917 | 0.79 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5146079 | 0.79 | ALDH1A1 (0.38) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5147380 | 0.78 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5147462 | 0.77 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL27688635 | 0.77 | QPCT (0.33) | — | |
| SCHEMBL5145889 | 0.77 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5147360 | 0.77 | CYP2A6 (0.35) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |