Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1811728 | 0.78 | — | — | |
| SCHEMBL193502 | 0.77 | CES2 (0.35) | WRN | |
| SCHEMBL21495021 | 0.77 | CES2 (0.35) | WRN | |
| SCHEMBL1849742 | 0.75 | GABBR2 (0.39) | WRN | |
| SCHEMBL21495048 | 0.75 | ALOX5 (0.40) | — | |
| SCHEMBL6865647 | 0.75 | ALOX5 (0.40) | — | |
| SCHEMBL5319115 | 0.75 | DAO (0.33) | — | |
| SCHEMBL28808975 | 0.71 | — | — | |
| SCHEMBL6128179 | 0.69 | GRM8 (0.37) | — | |
| SCHEMBL14058869 | 0.69 | ALOX5 (0.44) | WRN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057963-A1 | PIPERAZINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT | Boehringer Ingelheim International GmbH (DE) | 2016-08-24 | — | — | EP | disclosed |
| WO-2015055698-A1 | PIPERAZINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-04-23 | — | — | WO | disclosed |
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |