Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147380 | 0.89 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5148335 | 0.88 | PDE3B (0.36) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5147302 | 0.88 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5147360 | 0.87 | CYP2A6 (0.35) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5147318 | 0.86 | GAA (0.40) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL2986248 | 0.85 | ABL1 (0.31) | ABL1 | |
| SCHEMBL5145889 | 0.85 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5147363 | 0.85 | IKBKB (0.36) | ALDH1A1SMN1; SMN2HTTPLA2G7LMNA | |
| SCHEMBL5148348 | 0.84 | GAA (0.37) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL5147498 | 0.84 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2NPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | claimed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | claimed |
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |