Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5146010 | 0.88 | POLB (0.35) | ALDH1A1L3MBTL1SMN1; SMN2POLBHTT | |
| SCHEMBL5147313 | 0.88 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL5147380 | 0.87 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2HTTLMNARAB9A | |
| SCHEMBL2976991 | 0.86 | POLB (0.35) | ALDH1A1SMN1; SMN2POLBGSK3BLMNA | |
| SCHEMBL5148335 | 0.86 | PDE3B (0.36) | ALDH1A1SMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL5147509 | 0.86 | ALDH1A1 (0.38) | ALDH1A1L3MBTL1SMN1; SMN2POLBHTT | |
| SCHEMBL5145889 | 0.83 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2HTTLMNAKMT2A | |
| SCHEMBL5148348 | 0.82 | GAA (0.37) | ALDH1A1SMN1; SMN2HTTLMNARAB9A | |
| SCHEMBL5147498 | 0.82 | ALDH1A1 (0.36) | ALDH1A1SMN1; SMN2HTTKDM4ELMNA | |
| SCHEMBL5149190 | 0.82 | ALOX15 (0.38) | ALDH1A1SMN1; SMN2HTTLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |