Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2981950 | 0.87 | MAPK1 (0.33) | MAPK1ALDH1A1AXLMEN1KMT2A | |
| SCHEMBL5147508 | 0.76 | PLA2G7 (0.34) | PLA2G7ALDH1A1GRM2HTTSMN1; SMN2 | |
| SCHEMBL5149162 | 0.76 | PLA2G7 (0.40) | PLA2G7MAPK1ALDH1A1KDM4EGRM2 | |
| SCHEMBL5145980 | 0.75 | MAPK8 (0.34) | PLA2G7ALDH1A1GRM2AXL | |
| SCHEMBL5148389 | 0.75 | CA1 (0.35) | PLA2G7ALDH1A1GRM2 | |
| SCHEMBL5147316 | 0.74 | PLA2G7 (0.39) | PLA2G7MAPK1ALDH1A1KDM4EGRM2 | |
| SCHEMBL5147520 | 0.74 | PLA2G7 (0.35) | PLA2G7ALDH1A1GRM2 | |
| SCHEMBL5147391 | 0.73 | PLA2G7 (0.38) | PLA2G7MAPK1ALDH1A1KDM4EHTT | |
| SCHEMBL5148399 | 0.71 | PLA2G7 (0.39) | PLA2G7MAPK1ALDH1A1GRM2HTT | |
| SCHEMBL2973156 | 0.70 | CDK1 (0.40) | MAPK1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |