Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NMT2 | O60551 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2983794 | 0.87 | MEN1 (0.31) | ALDH1A1MEN1KMT2ALMNAUSP2 | |
| SCHEMBL5147401 | 0.82 | PLA2G7 (0.39) | PLA2G7ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL5146036 | 0.81 | HTT (0.35) | HTTALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL28770422 | 0.78 | NMT2 (0.33) | NMT2NMT1 | |
| SCHEMBL5148970 | 0.76 | ALDH1A1 (0.34) | PLA2G7HTTALDH1A1SMN1; SMN2GAA | |
| SCHEMBL5147336 | 0.73 | PLA2G7 (0.35) | PLA2G7HTTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5147385 | 0.73 | MAPK1 (0.35) | HTTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL5149162 | 0.72 | PLA2G7 (0.40) | PLA2G7ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5147424 | 0.72 | PLA2G7 (0.35) | PLA2G7ALDH1A1 | |
| SCHEMBL5147316 | 0.71 | PLA2G7 (0.39) | PLA2G7ALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |