Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 3/20 | 0.38 |
| ▸ | RAF1 | P04049 | 10/20 | 0.38 |
| ▸ | BRAF | P15056 | 10/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.36 |
| ▸ | FLT3 | P36888 | 2/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.36 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5149006 | 0.93 | ADORA1 (0.39) | ADORA1RAF1BRAFFGFR1FLT3 | |
| SCHEMBL5147476 | 0.88 | HSD17B1 (0.39) | ADORA1RAF1BRAFFGFR1FLT3 | |
| SCHEMBL5145850 | 0.88 | HSD17B1 (0.38) | ADORA1RAF1BRAFFGFR1FLT3 | |
| SCHEMBL2973501 | 0.87 | ADORA1 (0.39) | ADORA1RAF1BRAFFGFR1FLT3 | |
| SCHEMBL5149101 | 0.85 | RAF1 (0.37) | ADORA1RAF1BRAFFGFR1FLT3 | |
| SCHEMBL5147378 | 0.81 | ADORA1 (0.40) | ADORA1FGFR1ABL1MAPK14HTT | |
| SCHEMBL5145972 | 0.81 | RAF1 (0.39) | RAF1BRAFFGFR1FLT3ERN1 | |
| SCHEMBL5147429 | 0.80 | ADORA1 (0.37) | ADORA1BRAFABL1HTTMEN1 | |
| SCHEMBL5148381 | 0.80 | BRAF (0.39) | RAF1BRAFFGFR1FLT3ERN1 | |
| SCHEMBL2984465 | 0.80 | ADORA1 (0.39) | ADORA1RAF1BRAFFGFR1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |