Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | FYN | P06241 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5149053 | 0.91 | ALDH1A1 (0.41) | ADORA1ALDH1A1HTTADORA2AMEN1 | |
| SCHEMBL5147429 | 0.90 | ADORA1 (0.37) | ADORA1ALDH1A1HTTABL1MEN1 | |
| SCHEMBL2981953 | 0.87 | ADORA1 (0.41) | ADORA1FGFR1ABL1EGFRPDGFRB | |
| SCHEMBL5145833 | 0.85 | ALDH1A1 (0.43) | ADORA1ALDH1A1HTTABL1ADORA2A | |
| SCHEMBL5147347 | 0.81 | ADORA1 (0.38) | ADORA1ALDH1A1HTTFGFR1ABL1 | |
| SCHEMBL5146079 | 0.81 | ALDH1A1 (0.38) | ALDH1A1HTTMEN1KMT2AMAPK1 | |
| SCHEMBL5149006 | 0.81 | ADORA1 (0.39) | ADORA1ALDH1A1HTTFGFR1ABL1 | |
| SCHEMBL5145850 | 0.78 | HSD17B1 (0.38) | ADORA1ALDH1A1HTTFGFR1ABL1 | |
| SCHEMBL5147476 | 0.78 | HSD17B1 (0.39) | ADORA1ALDH1A1HTTFGFR1ABL1 | |
| SCHEMBL2981681 | 0.78 | ADORA1 (0.39) | ADORA1FGFR1ABL1EGFRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |