Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.37 |
| ▸ | ABL1 | P00519 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | BPTF | Q12830 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5149053 | 0.90 | ALDH1A1 (0.41) | ADORA1HTTMEN1KMT2AALDH1A1 | |
| SCHEMBL5147378 | 0.90 | ADORA1 (0.40) | ADORA1ABL1HTTMEN1KMT2A | |
| SCHEMBL2987755 | 0.86 | ADORA1 (0.37) | ADORA1ABL1BRAFMAPK1BPTF | |
| SCHEMBL5145833 | 0.84 | ALDH1A1 (0.43) | ADORA1ABL1HTTALDH1A1LMNA | |
| SCHEMBL5147280 | 0.83 | BRAF (0.37) | ADORA1ABL1HTTMEN1KMT2A | |
| SCHEMBL5146079 | 0.81 | ALDH1A1 (0.38) | HTTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5166707 | 0.81 | CDK1 (0.36) | HTTALDH1A1LMNAGAANPC1 | |
| SCHEMBL5147347 | 0.80 | ADORA1 (0.38) | ADORA1ABL1HTTMEN1KMT2A | |
| SCHEMBL5149006 | 0.80 | ADORA1 (0.39) | ADORA1ABL1HTTMEN1KMT2A | |
| SCHEMBL5147476 | 0.77 | HSD17B1 (0.39) | ADORA1ABL1HTTBRAFALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |