Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5148970 | 0.93 | ALDH1A1 (0.34) | PLA2G7ALDH1A1KDM4ELMNATSHR | |
| SCHEMBL5147424 | 0.87 | PLA2G7 (0.35) | PLA2G7ALDH1A1 | |
| SCHEMBL2977483 | 0.86 | MEN1 (0.31) | ALDH1A1MEN1USP2LMNACYP1A2 | |
| SCHEMBL5146036 | 0.84 | HTT (0.35) | ALDH1A1MEN1LMNATSHRKMT2A | |
| SCHEMBL5181907 | 0.83 | PLA2G7 (0.42) | PLA2G7ALDH1A1 | |
| SCHEMBL5147391 | 0.82 | PLA2G7 (0.38) | PLA2G7ALDH1A1KDM4EMEN1USP2 | |
| SCHEMBL2983807 | 0.79 | — | — | |
| SCHEMBL5149162 | 0.77 | PLA2G7 (0.40) | PLA2G7ALDH1A1KDM4EMEN1USP2 | |
| SCHEMBL27708086 | 0.77 | NMT2 (0.31) | — | |
| SCHEMBL5148346 | 0.75 | PLA2G7 (0.41) | PLA2G7ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |