Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9416233 | 0.83 | TPMT (0.47) | SMN1; SMN2HDAC8HDAC6KMT2ATP53 | |
| SCHEMBL162936 | 0.81 | ALDH1A1 (0.52) | SMN1; SMN2TDP1HPGDHDAC8HDAC6 | |
| SCHEMBL11852856 | 0.81 | MEN1 (0.49) | PARP1POLBMEN1KMT2AALDH1A1 | |
| SCHEMBL2705458 | 0.80 | HDAC3 (0.51) | SMN1; SMN2HDAC8HDAC6POLBMEN1 | |
| SCHEMBL4832150 | 0.79 | ALDH1A1 (0.50) | SMN1; SMN2TDP1HPGDHDAC8HDAC6 | |
| SCHEMBL11849614 | 0.77 | CES2 (0.54) | SMN1; SMN2HPGDPOLBRAB9AALDH1A1 | |
| SCHEMBL11842729 | 0.74 | TP53 (0.46) | SMN1; SMN2HDAC8HDAC6MEN1KMT2A | |
| SCHEMBL11854782 | 0.74 | MEN1 (0.53) | SMN1; SMN2HPGDHDAC8HDAC6POLB | |
| SCHEMBL18267481 | 0.73 | FAAH (0.49) | PARP1SMN1; SMN2TDP1HPGDHDAC8 | |
| SCHEMBL31309821 | 0.73 | FAAH (0.49) | PARP1SMN1; SMN2TDP1HPGDHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070112044-A1 | Thiadiazoline derivative | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2007-05-17 | — | — | US | disclosed |
| EP-1671957-A1 | THIADIAZOLINE DERIVATIVES | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2006-06-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112044-A1 | Thiadiazoline derivative | TLK2, TLK1, BRWD1 | PARP1 3025/4885SMN1; SMN2 3750/4885TDP1 1783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.