SCHEMBL5147587

SCHEMBL5147587

CCn1ncc(CNC(=O)OC(C)(C)C)c1NC(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CKS1B P61024 2/20 0.38
SKP1 P63208 2/20 0.38
SKP2 Q13309 2/20 0.38
KDM4A O75164 1/20 0.38
RORC P51449 1/20 0.38
KCNA5 P22460 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
ACSS2 Q9NR19 1/20 0.37
NAMPT P43490 2/20 0.36
BCHE P06276 1/20 0.35
SYK P43405 1/20 0.35
CYP1A2 P05177 1/20 0.35
MEN1 O00255 1/20 0.35
NPC1 O15118 1/20 0.35
GAA P10253 1/20 0.35
RAB9A P51151 1/20 0.35
KMT2A Q03164 1/20 0.35
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5148583 0.92 CKS1B (0.37) CKS1BSKP1SKP2KDM4ARORC
SCHEMBL5151955 0.90 DRD2 (0.39) CKS1BSKP1SKP2KDM4ARORC
SCHEMBL5148509 0.86 KDM4A (0.34) CKS1BSKP1SKP2KDM4AKCNA5
SCHEMBL5148538 0.84 KCNA5 (0.41) CKS1BSKP1SKP2KDM4AKCNA5
SCHEMBL5500498 0.82 NPFFR1 (0.36) CKS1BSKP1SKP2RORCACSS2
SCHEMBL5497926 0.80 TLR7 (0.38) CKS1BSKP1SKP2ACSS2BCHE
SCHEMBL5148607 0.75 KCNN4 (0.37) MEN1NPC1RAB9AKMT2AHPGD
SCHEMBL5148605 0.75 SIGMAR1 (0.43) CKS1BSKP1SKP2NAMPTBCHE
SCHEMBL5494835 0.75 ACSS2 (0.36) CKS1BSKP1SKP2ACSS2MEN1
SCHEMBL5500502 0.71 LMNA (0.32) ACSS2MEN1NPC1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7179801-B2 Cephem compounds ASTELLAS PHARMA INC. (JP) 2007-02-20 US disclosed
EP-1392704-B1 CEPHEM COMPOUNDS ASTELLAS PHARMA INC (JP) 2006-02-22 EP disclosed
US-20040248875-A1 Cephem compounds ASTELLAS PHARMA INC. (JP) 2004-12-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040248875-A1 Cephem compounds CEP170, C1S, SLC7A1 CKS1B 2346/4885SKP1 472/4885SKP2 1835/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.