Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | TACR2 | P21452 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5132935 | 0.87 | SIGMAR1 (0.49) | SIGMAR1HRH3 | |
| SCHEMBL1735359 | 0.83 | OPRM1 (0.46) | HTR1AHTR1DHTR2CHTR7HTR2B | |
| SCHEMBL7841889 | 0.82 | SIGMAR1 (0.65) | HTR1AHTR1DHTR2CHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL1734487 | 0.82 | OPRM1 (0.45) | HTR1AHTR1DHTR2CHTR7HTR2B | |
| Hydrochloric Acid SCHEMBL1414107 | 0.81 | SIGMAR1 (0.63) | HTR1AHTR1DHTR2CHTR7HTR2B | |
| SCHEMBL13605487 | 0.78 | DRD3 (0.44) | HTR1AHTR1DHTR2CHTR7HTR2B | |
| SCHEMBL1735198 | 0.77 | AVPR1B (0.48) | HTR1AHTR1DHTR2CHTR7HTR2B | |
| SCHEMBL13605739 | 0.76 | CACNA1G (0.45) | HTR1AHTR1DHTR2CHTR7HTR2B | |
| SCHEMBL1734153 | 0.76 | CACNA1G (0.45) | HTR1AHTR1DHTR2CHTR7HTR2B | |
| SCHEMBL1735308 | 0.73 | DRD3 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928236-A2 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM, LLC (BM) | 2008-06-11 | — | — | EP | disclosed |
| WO-2007038669-A2 | DIARYLAMINE-CONTAINING COMPOUNDS AND COMPOSITIONS, AND THEIR USE AS MODULATORS OF C-KIT RECEPTORS | IRM LLC (BM) | 2007-04-05 | — | — | WO | disclosed |