Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.61 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.55 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1414107 | 0.99 | SIGMAR1 (0.63) | SIGMAR1HRH3OPRM1GAALTA4H | |
| Hydrochloric Acid SCHEMBL1414248 | 0.86 | SIGMAR1 (0.61) | SIGMAR1HRH3OPRM1CACNA1GHTR1A | |
| SCHEMBL6990156 | 0.86 | S1PR5 (0.67) | SIGMAR1HRH3GAA | |
| SCHEMBL1414196 | 0.84 | KDM4E (0.61) | SIGMAR1HRH3OPRM1GAALTA4H | |
| SCHEMBL18117071 | 0.84 | KCNH2 (0.59) | HRH3OPRM1LTA4HHTR1AHTR2C | |
| Hydrochloric Acid SCHEMBL27696810 | 0.84 | OPRM1 (0.62) | SIGMAR1OPRM1 | |
| SCHEMBL10340077 | 0.83 | HTR2A (0.76) | OPRM1HTR2CHTR7KCNH2 | |
| SCHEMBL1735359 | 0.82 | OPRM1 (0.46) | SIGMAR1HRH3OPRM1LTA4HCACNA1G | |
| SCHEMBL5147945 | 0.82 | HTR1A (0.45) | SIGMAR1HRH3OPRM1LTA4HCACNA1G | |
| Hydrochloric Acid SCHEMBL9649705 | 0.82 | HTR2A (0.74) | OPRM1HTR2CHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0626968-B1 | PIPERIDINYL THIACYCLIC DERIVATIVES | MERRELL PHARMA INC (US) | 2001-09-26 | — | — | EP | disclosed |
| US-5739150-A | Piperidinyl thiacyclic derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1998-04-14 | — | — | US | disclosed |
| US-5650416-A | Piperidinyl thiacyclic derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-07-22 | — | — | US | disclosed |
| US-5631268-A | ANTIALLERGENS, 5HT2 RECEPTOR ANTAGONISTS | MERRELL PHARMACEUTICALS INC. (US) | 1997-05-20 | — | — | US | disclosed |
| CN-1147193-A | Insecticidal N-(substd. Arylmethyl)-4-[bis(substd. phenyl) methyl] piperidines | FMC CORP (US) | 1997-04-09 | — | — | CN | disclosed |
| US-5602147-A | Piperidinyl thiacyclic derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-02-11 | — | — | US | disclosed |
| US-5596003-A | Piperidinyl thiacyclic derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5541200-A | Piperidinyl thiacyclic derivatives | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5476861-A | Piperidinyl thiacyclic derivatives | MERRELL DOW PHARMACEURICALS INC. (US) | 1995-12-19 | — | — | US | disclosed |
| EP-0363963-B1 | Piperidinyl benzimidazoles as antihistamines | MERRELL DOW PHARMA (US) | 1995-04-26 | — | — | EP | disclosed |
| EP-0626968-A4 | — | — | 1995-01-04 | — | — | EP | disclosed |
| EP-0626968-A1 | PIPERIDINYL THIACYCLIC DERIVATIVES | MERRELL PHARMACEUTICALS INC. (US) | 1994-12-07 | — | — | EP | disclosed |
| US-5371093-A | Piperidinyl thiacyclic derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-12-06 | — | — | US | disclosed |
| WO-1993016081-A1 | PIPERIDINYL THIACYCLIC DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-19 | — | — | WO | disclosed |
| US-5182399-A | Process for preparing piperidinyl benzimidazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0363963-A1 | Piperidinyl benzimidazoles as antihistamines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-04-18 | — | — | EP | disclosed |
| US-4908372-A | Antihistaminic piperidinyl benzimidazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-13 | — | — | US | disclosed |