Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | PGK1 | P00558 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147380 | 0.82 | ALDH1A1 (0.40) | MERTKPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2975085 | 0.82 | MERTK (0.35) | MERTKPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL5148423 | 0.80 | FPR2 (0.34) | MERTKPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2975235 | 0.79 | MERTK (0.34) | MERTKPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL5149156 | 0.79 | MERTK (0.35) | MERTKPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2984215 | 0.78 | JAK2 (0.33) | MERTKPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2985538 | 0.78 | SCN9A (0.42) | MERTKADORA2AADORA1 | |
| SCHEMBL5183786 | 0.78 | USP2 (0.33) | MERTKPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2982366 | 0.78 | MERTK (0.34) | MERTKPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2971865 | 0.77 | CCNC (0.33) | MERTKPIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |