Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 2/20 | 0.32 |
| ▸ | CDK8 | P49336 | 2/20 | 0.32 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2982366 | 0.85 | MERTK (0.34) | MERTKKCNH2PIK3CAPIK3CDPIK3CB | |
| SCHEMBL5149073 | 0.84 | ILK (0.35) | PLA2G7 | |
| SCHEMBL5147380 | 0.84 | ALDH1A1 (0.40) | MERTKPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2985538 | 0.84 | SCN9A (0.42) | MERTKKCNH2CCNCCDK8PRKCQ | |
| SCHEMBL2975235 | 0.83 | MERTK (0.34) | MERTKKCNH2PIK3CAPIK3CDPIK3CB | |
| SCHEMBL2986555 | 0.82 | SCN9A (0.37) | MERTKKCNH2PIK3CDCCNCCDK8 | |
| SCHEMBL5148423 | 0.82 | FPR2 (0.34) | MERTKPIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL2974918 | 0.81 | JAK2 (0.33) | MERTKKCNH2PIK3CAPIK3CDPIK3CB | |
| SCHEMBL2975085 | 0.80 | MERTK (0.35) | MERTKKCNH2PIK3CAPIK3CDPIK3CB | |
| SCHEMBL2984215 | 0.80 | JAK2 (0.33) | MERTKPIK3CAPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |