Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | GALR3 | O60755 | 1/20 | 0.54 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.54 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5149238 | 0.83 | SIGMAR1 (0.72) | SIGMAR1HTR2AHTR2CHTR7KMT2A | |
| SCHEMBL9635340 | 0.80 | PDE4D (0.57) | HTTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8595287 | 0.79 | HTR7 (0.54) | HTTLMNASMN1; SMN2RAB9AMCOLN3 | |
| SCHEMBL14468188 | 0.79 | SIGMAR1 (0.74) | SIGMAR1ALDH1A1L3MBTL1HTR2AHTR2C | |
| SCHEMBL5431476 | 0.79 | SIGMAR1 (0.59) | SIGMAR1LMNATSHRALDH1A1HSD17B10 | |
| SCHEMBL14093583 | 0.79 | PDE4D (0.59) | HTTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14445631 | 0.78 | SIGMAR1 (0.69) | SIGMAR1SMN1; SMN2ALDH1A1HSD17B10HTR2A | |
| SCHEMBL4271065 | 0.78 | SIGMAR1 (0.97) | SIGMAR1ALDH1A1HSD17B10CXCR4 | |
| SCHEMBL6371454 | 0.77 | PDE4D (0.57) | HTTLMNASMN1; SMN2RAB9ANPC1 | |
| SCHEMBL14093582 | 0.76 | PDE4D (0.56) | HTTLMNASMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878736-B1 | Histamine H3 receptor ligands | JAMES BLACK FOUNDATION LIMITED (GB) | 2005-04-12 | — | — | US | disclosed |
| EP-1056733-B1 | HISTAMINE H3 RECEPTOR LIGANDS | BLACK JAMES FOUNDATION (GB) | 2004-01-07 | — | — | EP | disclosed |
| EP-1056733-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999042458-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-08-26 | — | — | WO | disclosed |