Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.59 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5149238 | 0.83 | SIGMAR1 (0.72) | SIGMAR1SRCCXCR4 | |
| SCHEMBL10860489 | 0.83 | LMNA (0.55) | ALDH1A1TSHRHSD17B10TDP1LMNA | |
| SCHEMBL6338588 | 0.79 | SIGMAR1 (0.62) | SIGMAR1ALDH1A1TSHRHSD17B10DRD3 | |
| SCHEMBL14574205 | 0.79 | LMNA (0.50) | ALDH1A1TSHRHSD17B10TDP1LMNA | |
| SCHEMBL2852904 | 0.77 | KMT2A (0.56) | ALDH1A1TSHRHSD17B10TDP1LMNA | |
| SCHEMBL14468188 | 0.76 | SIGMAR1 (0.74) | SIGMAR1SRCALDH1A1CXCR4 | |
| SCHEMBL8251507 | 0.75 | LMNA (0.53) | ALDH1A1TSHRHSD17B10TDP1LMNA | |
| SCHEMBL4271065 | 0.75 | SIGMAR1 (0.97) | SIGMAR1SRCALDH1A1HSD17B10CXCR4 | |
| SCHEMBL13091569 | 0.75 | MEN1 (0.49) | SIGMAR1ALDH1A1TSHRHSD17B10TDP1 | |
| SCHEMBL27746879 | 0.75 | SIGMAR1 (0.68) | SIGMAR1SRCALDH1A1CXCR4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161645-A1 | Thiazole inhibitors targeting resistant kinase mutations | TARGEGEN, INC. (US) | 2007-07-12 | — | — | US | disclosed |
| US-20070161645-A1 | Thiazole inhibitors targeting resistant kinase mutations | TARGEGEN, INC. (US) | 2007-07-12 | — | — | US | disclosed |
| US-20070161645-A1 | Thiazole inhibitors targeting resistant kinase mutations | TARGEGEN, INC. (US) | 2007-07-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161645-A1 | Thiazole inhibitors targeting resistant kinase mutations | JAK2, ABL1, FLT3 | SIGMAR1 4184/4885SRC 78/4885ALDH1A1 1806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.